The Proportion of Regulatory T cells in Patients with Sjogren's syndrome: A Meta-Analysis
Sjogren's syndrome is a common autoimmune condition marked by eye dryness, exhaustion, and pain. Regulatory T cells play a role in the disease pathogenesis. Patients with SS had a lower proportion of Tregs in their peripheral blood (P0.001). The number of CD4+ and CD25+ Treg cells in SS patients was considerably lower than in the control group.
Upadacitinib or Adalimumab in Patients with Rheumatoid Arthritis: Safety and Efficacy
In phase 3 trial of SELECT-COMPARE, upadacitinib 15 mg daily showed improvement in clinical symptoms of RA compared to adalimumab plus MTX at week 12. Over a 3-year period, the trial compared the safety and efficacy of UPA versus ADA with an added dose of MTX. A higher proportion of patients taking UPA achieved disease activity & higher rates of ACR responses. UPA+MTX showed better response .
