Lecanemab Helps Reduce Amyloid Markers in Patients with Early Alzheimer’s Disease
Lecanemab, a humanized IgG1 monoclonal antibody that binds to Aβ soluble protofibrils, was tested in persons with early Alzheimer’s disease. Lecanemab reduced markers of amyloid in early Alzheimer’s and resulted in moderately less decline on measures of cognition and function at 18 months but was associated with adverse events. Longer trials are warranted to determine its safety.
Frequently Eating French Fries may Increase the Risk for Anxiety and Depression
In multivariable analyses, fried food consumption increased the risk for anxiety by 12% and depression by 7%. Specifically, fried potato were associated with a 4% greater risk for anxiety and 2% risk for depression. The link were strongest in men and younger people. It was found that long-term exposure to acrylamidea dangerous fried food contaminant, elicited anxiety and depression behaviors.
Prenatal Depression may Increase the Risk of Cardiovascular Disease After Childbirth
People with prenatal depression have high cardiovascular disease risk within 2 years of delivery.83% higher risk of ischemic heart disease; 60% higher risk of arrhythmia/cardiac arrest; 61% higher risk of cardiomyopathy; and 32% higher risk of new high blood pressure diagnosis. Additional pregnancy-related factors contributing to CVD may include chronic inflammation and stress-related hormones.
SHMOOSE - Unique Microprotein Associated With High Risk of Alzheimer's
A new study found that a mutation in one particular mitochondrial SNP was associated with a greater risk of Alzheimer’s disease and brain atrophy. The mutated SNP causes a change in a mitochondrial microprotein called SHMOOSE. The protein appears to have a physiological role in neurodegeneration. The finding opens new avenues for detecting, preventing, and treating Alzheimer’s disease.
Why Women Have High Risk of Alzheimer's Than Men?
Women with AD have greater accumulations of tau protein in brains. Human AD brain tissue analysis shows that increased levels of X-linked ubiquitin specific peptidase 11 (USP11) in females results in increased deubiquitination of tau at lysine (K) 281, which increases tau deposition by inhibiting its elimination. This contributes to cognitive impairment, with greater effect in females than males.
